OXIDATIVE AND EXCITATORY NEUROTOXIC STRESSES IN CRISPR/CAS9-INDUCED KYNURENINE AMINOTRANSFERASE KNOCKOUT MICE: A NOVEL MODEL FOR DESPAIR-BASED DEPRESSION AND POST-TRAUMATIC STRESS DISORDER

Backgrounds: Memory and emotion are especially vulnerable to psychiatric disorders such as post-traumatic stress disorder (PTSD), which is linked to disruptions in serotonin (5-HT) metabolism.Over 90% of the 5-HT precursor tryptophan (Trp) is metabolized via the Trp-kynurenine (KYN) metabolic pathway, which generates a variety of bioactive molecule

Aspect-level sentiment analysis within multimodal contexts, focusing on the precise identification and interpretation of sentiment attitudes linked to the target aspect across diverse data modalities, remains a focal research area that perpetuates the advancement of discourse and innovation in artificial intelligence.However, most existing methods

raceline renegade 8 16x10 Abstract Background Inteins are mobile, self-splicing sequences that interrupt proteins and occur across all three domains of life.Scrutiny of the intein landscape in prokaryotes led to the hypothesis that some inteins are functionally important.Our focus shifts to eukaryotic inteins to assess their diversity, distribution

Abstract AXL, a receptor tyrosine kinase, has recently emerged as a potential therapeutic target hydrangea red sensation against various types of cancer.Gilteritinib, a FDA-approved small-molecule inhibitor, is used for the treatment of patients with FLT3-mutated acute myeloid leukemia.However, the antitumor activity of gilteritinib in solid tumors